CECs

Brian Harvey PDF Print E-mail
Brian Harvey holds primary degrees in mathematics, physics and physiology. He obtained his PhD in membrane biophysics under the supervision of Roddy Kernan at the National University of Ireland in 1982. He carried out his post-doctoral studies at the Commissariat à l’Energie Atomique, Molecular Biology Laboratories in Villefranche-sur-mer, France, where he was appointed to a permanent position in 1986 as Chargé de Recherche. Brian returned to Ireland in 1992 as Professor of Cell and Molecular Physiology at University College Cork where he established the Wellcome Trust Cellular Physiology Research Unit. In 2002, he was recruited to The Royal College of Surgeons in Ireland as Professor of Molecular Medicine at Beaumont Hospital, Dublin, and Director of the RCSI Research Institute. In addition to his academic roles, Brian was Ireland’s first and longest serving University Vice-President for Research from 1998-2010 and Director of Research at the International DOCTRID Research Institute from 2010-2017. Brian has received international honours for his scholarship and research. He was made a Chevalier of the French Order of Merit in 2006 by The President of France and a Chevalier de l’Ordre des Palmes Academiques in 2016. He was the first recipient of the International Laureat Prix Servier in 2008. He was appointed Visiting Research Professor at the Université de Paris Descartes in 2013.

In 2000, Brian was elected to the European Academy of Sciences and in 2007 elected to the Royal Irish Academy and was a Founding Fellow of the Irish Academy of Medical Sciences. He was awarded a Doctor of Science honoris causa from Michigan State University in 2013. Brian served on the European Research Council Advanced Awards Panel from 2008-2016 and was President of the French National Research Agency Scientific Evaluation Council from 2015-2017. His current research focuses on the cellular and molecular mechanisms of steroid hormone actions in inflammation and cancer. He has published more than 280 articles in international scientific journals (ORCID Researcher ID orcid.org/0000-0002-7388-8034). Brian has a long-standing collaboration with CECs and has trained PhDs and Post-doctoral fellows from Chile since 2000.
 
SELECTED PUBLICATIONS
 
Bustos V, Nolan AM, Nijhuis A, Harvey H, Parker A, Poulsom R, McBryan J, Thomas W, Silver A and Harvey BJ. GPER mediates differential effects of estrogen on colon cancer cell proliferation and migration under normoxic and hypoxic conditions. Oncotarget. 2017; 8:84258-84275.

Rapetti-Mauss R, Bustos V, Thomas W, McBryan J, Harvey H, Lajczak N, Madden SF, Pellissier B, Borgese F, Soriani O, Harvey BJ. Bi-directional KCNQ1:β-catenin interaction drives colorectal cancer cell differentiation. Proc Natl Acad Sci USA. 2017 Apr 18;114(16):4159-4164.

Higgins, G., Torre, C.F., Tyrrell, J., McNally, P., Harvey, B.J., Urbach, V. Lipoxin A4 prevents tight junction disruption and delays the colonization of cystic fibrosis bronchial epithelial cells by Pseudomonas aeruginosa. (2016) American Journal of Physiology - Lung Cellular and Molecular Physiology, 310 (11), pp. L1053-L1061.

Humphreys, H., Fitzpatick, F., Harvey, B.J. Gender differences in rates of carriage and bloodstream infection caused by methicillin-resistant staphylococcus aureus: Are they real, do they matter and why? (2015) Clinical Infectious Diseases, 61 (11), pp. 1708-1714.

Yusef, Y.R., Thomas, W., Harvey, B.J. Estrogen increases ENaC activity via PKCδ signaling in renal cortical collecting duct cells. (2014) Physiological Reports, 2 (5), art. no. e12020, 15 p.

Drumm, B.T., Sergeant, G.P., Hollywood, M.A., Thornbury, K.D., McHale, N.G., Harvey, B.J. The role of cAMP dependent protein kinase in modulating spontaneous intracellular Ca2+ waves in interstitial cells of Cajal from the rabbit urethra. (2014) Cell Calcium, 56 (3), pp. 181-187.

Saint-Criq, V., Kim, S.H., Katzenellenbogen, J.A., Harvey, B.J. Non-genomic estrogen regulation of ion transport and airway surface liquid dynamics in cystic fibrosis bronchial epithelium. (2013) PLoS ONE, 8 (11), art. no. e78593.

Dooley, R., Angibaud, E., Yusef, Y.R., Thomas, W., Harvey, B.J. Aldosterone-induced ENaC and basal Na+/K+-ATPase trafficking via protein kinase D1-phosphatidylinositol 4-kinaseIIIβ trans Golgi signalling in M1 cortical collecting duct cells. (2013) Molecular and Cellular Endocrinology, 372 (1-2), pp. 86-95.

Rapetti-Mauss, R., O'Mahony, F., Sepulveda, F.V., Urbach, V., Harvey, B.J. Oestrogen promotes KCNQ1 potassium channel endocytosis and postendocytic trafficking in colonic epithelium. (2013) Journal of Physiology, 591 (11), pp. 2813-2831.

Pedram, A., Razandi, M., O'Mahony, F., Harvey, H., Harvey, B.J., Levin, E.R. Estrogen reduces lipid content in the liver exclusively from membrane receptor signaling. (2013) Science Signaling, 6 (276), art. no. ra36.

Mahony, F., Razandi, M., Pedram, A., Harvey, B.J., Levin, E.R. Estrogen modulates metabolic pathway adaptation to available glucose in breast cancer cells. (2012) Molecular Endocrinology, 26 (12), pp. 2058-2070.

Chotirmall, S.H., Smith, S.G., Gunaratnam, C., Cosgrove, S., Dimitrov, B.D., O'Neill, S.J., Harvey, B.J., Greene, C.M., McElvaney, N.G.Effect of estrogen on pseudomonas mucoidy and exacerbations in cystic fibrosis. (2012) New England Journal of Medicine, 366 (21), pp. 1978-1986.

Dooley, R., Harvey, B.J., Thomas, W. Non-genomic actions of aldosterone: From receptors and signals to membrane targets. (2012) Molecular and Cellular Endocrinology, 350 (2), pp. 223-234.

Alzamora, R., O'Mahony, F., Bustos, V., Rapetti-Mauss, R., Urbach, V., Cid, L.P., Sepúlveda, F.V., Harvey, B.J. Sexual dimorphism and oestrogen regulation of KCNE3 expression modulates the functional properties of KCNQ1 K+ channels. (2011) Journal of Physiology, 589 (21), pp. 5091-5107.

Thomas, W., Harvey, B.J. Mechanisms underlying rapid aldosterone effects in the kidney. (2011) Annual Review of Physiology, 73, pp. 335-357.

Chotirmall, S.H., Greene, C.M., Oglesby, I.K., Thomas, W., O'Neill, S.J., Harvey, B.J., McElvaney, N.G. 17β-estradiol inhibits IL-8 in cystic fibrosis by up-regulating secretory leucoprotease inhibitor. (2010) American Journal of Respiratory and Critical Care Medicine, 182 (1), pp. 62-72.

O'Mahony, F., Thomas, W., Harvey, B.J.Novel female sex-dependent actions of oestrogen in the intestine. (2009) Journal of Physiology, 587 (21), pp. 5039-5044.

O'Mahony, F., Alzamora, R., Chung, H.-L., Thomas, W., Harvey, B.J. Genomic priming of the antisecretory response to estrogen in rat distal colon throughout the estrous cycle. (2009) Molecular Endocrinology, 23 (11), pp. 1885-1899.

McEneaney, V., Harvey, B.J., Thomas, W. Aldosterone regulates rapid trafficking of epithelial sodium channel subunits in renal cortical collecting duct cells via protein kinase D activation. (2008) Molecular Endocrinology, 22 (4), pp. 881-892.

Condliffe, S.B., Doolan, C.M., Harvey, B.J. 17β-Oestradiol acutely regulates Cl- secretion in rat distal colonic epithelium. (2001) Journal of Physiology, 530 (1), pp. 47-54.
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