Carlos Flores
Pinilla Carlos Alejandro Flores was born in Temuco in 1973 and graduated from highschool the Liceo A-28 Pablo Neruda, of that city. In 1996 he completed his studies as a Medical Technologist at the Universidad de La Frontera in Temuco, a race he never exercised. Convinced that medical sciences and life in a laboratory can be intellectually defiant and avoiding the hours of 8 to 5, shirt and tie, opted in 1999, at the Universidad de Concepción as a student of Masters in Physiology in the laboratory of Dr Luis Sobrevía, where he began his walk as a scientist. Here he worked mainly in the metabolism of nitric oxide and L-arginine transport in human endothelium in relation to vascular disorders associated with diabetes. Part of the work of his thesis is developed at King's College London, by a research stay at the laboratory of Dr. Giovanni Mann. In 2002 Carlos joined to CECs, reaches the middle of that same year he joined the Ph.D. in the Universidad Austral de Chile, he got PhD in 2007 under the tutelage of Dr. Francisco V. Sepúlveda. During his years at the CECs, Carlos has worked studying the role of ion channels in epilepsy and physiology of the intestine. Currently as Postdoctoral CECs is interested in using animal models to study transepithelial transport, intestinal complications arising from cystic fibrosis and the role of certain ion channels as potential therapeutic targets of the disease.
Contreras-Baeza Y, Sandoval PY, Alarcón R, Galaz A, Cortés-Molina F, Alegría K, Baeza-Lehnert F, Arce-Molina R, Guequén A, Flores CA, San Martín A, Barros LF. Monocarboxylate Transporter 4 (MCT4) Is a High Affinity Transporter Capable of Exporting Lactate in High-Lactate Microenvironments. Journal of Biological Chemistry. 294: 20135-20147 2019.

Vega G, Guequén A, Johansson MEV, Arike L, Martínez-Abad B, Nyström EEL, Scudieri P, Pedemonte N, Millar-Büchner P, Philp AR, Galietta LJ, Hansson GC & Flores CA. Normal Calcium-Activated Anion Secretion in a Mouse Selectively Lacking TMEM16A in Intestinal Epithelium. Frontiers in Physiology. 10: 694, 2019.

Philp AR, Riquelme TT, Millar-Büchner P, González R, Sepúlveda FV, Cid LP & Flores CA. Kcnn4 is a modifier gene of intestinal cystic fibrosis preventing lethality in the Cftr-F508del mouse. Scientific Reports. 8: 9320, 2018.

Millar-Büchner P, Philp AR, Gutierrez N, Villanueva S, Kerr B & Flores CA. Severe changes in colon epithelium in the Mecp2-null mouse model of Rett syndrome. Molecular and Cellular Pediatrics. 3:37, 2016.

Flores CA. ClC-2 channels and intestinal chloride secretion. American Journal of Physiology. Gastrointestinal and Liver Physiology. 311:G775, 2016.

Gianotti A, Ferrera L, Philp AR, Caci E, Zegarra-Moran O, Galietta LJ & Flores CA. Pharmacological analysis of epithelial chloride secretion mechanisms in adult murine airways. European Journal of Pharmacology. 781:100-8, 2016.

Henríquez C, Riquelme TT, Vera D, Julio-Kalajzić F, Ehrenfeld P, Melvin JE, Figueroa CD, Sarmiento J & Flores CA. The calcium-activated potassium channel Kca 3.1 plays a central role in the neutrophil chemotactic response. Acta Physiologica. 1:132-145, 2016.

Catalán MA, Flores CA, Gonzalez-Begne M, Zhang Y, Cid LP, Sepúlveda FV & Melvin JE. Severe defects in absorptive ion transport in distal colon of mice that lack ClC-2 Channels. Gastroenterology. 142: 346-354, 2012.

Telephone: +56-63- 234503
Fax : +56-63-234517
E-mail :lc.scec@serolfc